Rescue via Genetic Findings
نویسندگان
چکیده
منابع مشابه
Genetic rescue to the rescue.
Genetic rescue can increase the fitness of small, imperiled populations via immigration. A suite of studies from the past decade highlights the value of genetic rescue in increasing population fitness. Nonetheless, genetic rescue has not been widely applied to conserve many of the threatened populations that it could benefit. In this review, we highlight recent studies of genetic rescue and pla...
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Genetic rescue is a potentially effective management tool to offset the effects of reduced genetic diversity in imperiled populations. However, implementation requires complex choices. Here we address the consequences of introducing males versus females, highlighting the possibility that introduced females might lead to maladapted mitonuclear genomes and reduced offspring fitness.
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Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). To determine the long-term effects of exercise, we implemented a mild exercise regimen in a mouse model of SCA1 and found a considerable improvement in survival accompanied by up-regulation of epidermal growth factor and consequential down-regulation of C...
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The mammalian circadian system contains both central and peripheral oscillators. To understand the communication pathways between them, we have studied the rhythmic behavior of mouse embryo fibroblasts (MEFs) surgically implanted in mice of different genotypes. MEFs from Per1(-/-) mice have a much shorter period in culture than do tissues in the intact animal. When implanted back into mice, how...
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Here we report on the clinical findings and key symptoms in WNT10A-related ectodermal dysplasias. The ectodermal dysplasias (ED) are a large, heterogeneous group of disorders characterized by defects in the morphogenesis of skin, sweat, sebaceous, submucous, and mammary glands, hair, nails and teeth. Numerous more or less distinct entities have been reported, however, most of them are very rare...
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ژورنال
عنوان ژورنال: Hastings Center Report
سال: 2018
ISSN: 0093-0334
DOI: 10.1002/hast.844